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This paper explores the social dynamics of zoonotic disease exposure, demonstrating how risks are not generalised, but are related to occupation, gender, class and other dimensions of social difference. Through case studies of Lassa Fever in Sierra Leone, Henipah virus in Ghana, Rift Valley Fever in Kenya and Trypanosomiasis in Zimbabwe, the paper proposes a social difference space–time framework to assist the understanding of and response to zoonotic diseases within a ‘One Health’ approach.

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